Breakthrough Technologies For Better Separations
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1 Why To Choose Chrom-Matrix Sample Preparation Products and Methodologies?
In contrast to the main trends in the literatures and marketing manuals of all the other chromatographic vendors, Chrom-Matrix strongly recommends
to use silica-based bonded phases for most of your applications. Furthermore, a few refined mixed-mode and/or weak ion-exchange sorbents with high
selectivity generally offer cleaner background and higher recoveries than conventional C18 and polymer phases.
The goal of sample preparation is to accurately and precisely extract desired (multi-) targets, and if necessary, metabolites, frequently in the parts per
billion concentrations from bulk matrices for further analysis. Higher recoveries and elimination of matrix effect are two key standards for evaluation of
sample preparation technologies. Actually, most of the current methods such as acetontrile protein crash, liquid-liquid extraction, polymer-based SPE,
conventional C18, C8, C4, Phenyl, strong ion-exchange, on-line SPE, restricted access media, column switch-on technology, turbulent flow,
super-critical fluidextraction, monolithic sorbents do not meet acceptance criteria and the manufacturer are misleading customers.
Chrom-Matrix Inc. has applied for patent protection and promotes WAX-enhanced extraction methodologies for elimination of matrix effect in
quantitative bioanalysis.
Chrom-Matrix Inc. submits a peer-reviewed article titled as "Uses of An Improved Version of C8 + SCX Mixed-mode SPE for Cleaner Extraction of Basic
and Zwitterionic Compounds from Biological Fluids".
Chrom-Matrix Inc. submits a peer-reviewed article titled as "Use of PSA and Optimized Elution Protocols
for Cleanup of Food and Agriculture Products"
We have served dozens of customers for development and validation of unbeatable sample preparation, HPLC and LC/MS/MS methods.
2. List of Sample Preparation Products
(1) SPE sorbents for reduction and elimination of matrix effects in LC/MS and GC-MS Bioanalysis
- PSA
- Aminopropyl
- C8 + WAX Mixed-mode SPE
- C8 + SAX Mixed-mode SPE
(2) Systematic Toxicological Analysis and Drug Screening
- C8 + SCX Mixed-mode SPE
(3) Multi-class Pesticide Analysis in Agricultural Products
- PSA
(4) General purposes
- C18
- C8
- Phenyl
Our sample preparation products are available in bulk materials, cartridges and 96-well formats. Bulk materials can be used as dispersed format to
combine with other extraction methods for elimination of matrix effect. For cartridge and 96-well format, a simple manifold is required for operation (see
figure below):
In contrast to the main trends in the literatures and marketing manuals of all the other chromatographic vendors, Chrom-Matrix strongly recommends
to use silica-based bonded phases for most of your applications. Furthermore, a few refined mixed-mode and/or weak ion-exchange sorbents with high
selectivity generally offer cleaner background and higher recoveries than conventional C18 and polymer phases.
The goal of sample preparation is to accurately and precisely extract desired (multi-) targets, and if necessary, metabolites, frequently in the parts per
billion concentrations from bulk matrices for further analysis. Higher recoveries and elimination of matrix effect are two key standards for evaluation of
sample preparation technologies. Actually, most of the current methods such as acetontrile protein crash, liquid-liquid extraction, polymer-based SPE,
conventional C18, C8, C4, Phenyl, strong ion-exchange, on-line SPE, restricted access media, column switch-on technology, turbulent flow,
super-critical fluidextraction, monolithic sorbents do not meet acceptance criteria and the manufacturer are misleading customers.
Chrom-Matrix Inc. has applied for patent protection and promotes WAX-enhanced extraction methodologies for elimination of matrix effect in
quantitative bioanalysis.
Chrom-Matrix Inc. submits a peer-reviewed article titled as "Uses of An Improved Version of C8 + SCX Mixed-mode SPE for Cleaner Extraction of Basic
and Zwitterionic Compounds from Biological Fluids".
Chrom-Matrix Inc. submits a peer-reviewed article titled as "Use of PSA and Optimized Elution Protocols
for Cleanup of Food and Agriculture Products"
We have served dozens of customers for development and validation of unbeatable sample preparation, HPLC and LC/MS/MS methods.
2. List of Sample Preparation Products
(1) SPE sorbents for reduction and elimination of matrix effects in LC/MS and GC-MS Bioanalysis
- PSA
- Aminopropyl
- C8 + WAX Mixed-mode SPE
- C8 + SAX Mixed-mode SPE
(2) Systematic Toxicological Analysis and Drug Screening
- C8 + SCX Mixed-mode SPE
(3) Multi-class Pesticide Analysis in Agricultural Products
- PSA
(4) General purposes
- C18
- C8
- Phenyl
Our sample preparation products are available in bulk materials, cartridges and 96-well formats. Bulk materials can be used as dispersed format to
combine with other extraction methods for elimination of matrix effect. For cartridge and 96-well format, a simple manifold is required for operation (see
figure below):
